| Phillips 66 | Westchase | 1 de mayo de 2012 |
| PNC Financial Services | One PNC Plaza | 1982 |
| Polycom | San José | 1990 |
| Procter & Gamble | Ohio, Cincinnati | 31 de octubre de 1837 |
| Progressive Corporation | Mayfield | 10 de marzo de 1937 |
| Qorvo | Greensboro | 2015 |
| Quiksilver | Huntington Beach | 1969 |
| Rackspace | — | 1998 |
| Ralph Lauren Corporation | Nueva York | 1967 |
| Rambus | Sunnyvale | 1990 |
| Raytheon | Waltham | 7 de julio de 1922 |
| Raytheon Technologies Corporation | condado de Arlington | 3 de abril de 2020 |
| Realty income | San Diego | 1969 |
| Regeneron Pharmaceuticals | Eastview | 1988 |
| Revlon | Nueva York | 1932 |
| Robinhood | Palo Alto | 2013 |
| Roblox Corporation | San Mateo | 2004 |
| Rockwell International | Estados Unidos | febrero 1973 |
| Roku, Inc | Los Gatos | octubre 2002 |
| Ross Stores | Dublin | 1954 |
| Royal Caribbean Group | Miami | 1997 |
| RR Donnelley | Chicago | 1864 |
| Ruby Tuesday | — | 1972 |
| Safeway | Pleasanton | 1915 |
| Salesforce | Salesforce Tower, San Francisco | 3 de febrero de 1999 |
| Schlumbergerinida | Houston | 1926 |
| Sealy Corporation | Trinity | 1881 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| Semrush | Boston | 3 de agosto de 2008 |
| Sigma-Aldrich | San Luis | 1976 |
| Similarweb | Guivatayim | 2007 |
| Skechers | Manhattan Beach | 1992 |
| Skydance Corporation | Los Ángeles, One Astor Plaza | 7 de agosto de 2025 |
| Smith & Wesson | Springfield | 1852 |
| Smithfield Foods | Smithfield | 1936 |
| Snowflake Inc. | San Mateo | 2012 |
| SoFi | San Francisco | 26 de abril de 2011 |
| SolarCity | San Mateo, California | 2006 |
| SolarWinds | Austin | 1999 |
| Sonos | Santa Bárbara | 2002 |
| Southern Company | Atlanta | 1945 |
| Spectrum Brands | Middleton | 1906 |
| Spirit AeroSystems | Wichita | 1927 |
| Sprouts | Phoenix | julio 2002 |
| Staples Inc. | Framingham | 1986 |
| State Street Corporation | Boston | 1792 |
| STX Entertainment | Burbank | 10 de marzo de 2014 |
| Sun Microsystems | Santa Clara | 24 de febrero de 1982 |