| Salesforce | Salesforce Tower, San Francisco | 3 de febrero de 1999 |
| SanDisk | Milpitas | 1 de junio de 1988 |
| Santa Cruz Operation | Santa Cruz | 1979 |
| Schlumbergerinida | Houston | 1926 |
| Scripps-Booth | Detroit | 1913 |
| SDI Media Group | Culver City | 1965 |
| Seabourn Cruise Line | Seattle, Miami | 1986 |
| Sealy Corporation | Trinity | 1881 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| Seattle's Best Coffee | Seattle | 1991 |
| Semiconductor Cypress | San José | 1982 |
| Semrush | Boston | 3 de agosto de 2008 |
| Shaba Games | San Francisco | 1997 |
| Sheaffer | Shelton | 1912 |
| Shelby SuperCars | West Richland | 1999 |
| Shen Yun | Deerpark | 2006 |
| Sheraton Hotels & Resorts | White Plains | 1937 |
| Shield AI | San Diego | 28 de mayo de 2015 |
| Shimmer Women Athletes | Illinois, Chicago, Berwyn | 6 de noviembre de 2005 |
| Shure Incorporated | Niles | 1925 |
| Siebel Systems | Austin | 1993 |
| Sierra Nevada Corporation | Sparks | 1963 |
| Sigma-Aldrich | San Luis | 1976 |
| Silver Lake | Menlo Park | 1999 |
| Silver Pictures | Los Ángeles | 1980 |
| Similarweb | Guivatayim | 2007 |
| Singer Corporation | La Vergne, Estados Unidos, Edificio Singer | 1851 |
| Skechers | Manhattan Beach | 1992 |
| Sketchfab | Nueva York | 2012 |
| Sky & Telescope | — | 1941 |
| Skydance Media | Hollywood | 2006 |
| Skywalker Sound | Lucas Valley | 1975 |
| Smith & Wesson | Springfield | 1852 |
| Smithfield Foods | Smithfield | 1936 |
| Snowflake Inc. | San Mateo | 2012 |
| Sociedad de Ingenieros Automotrices | Warrendale | 1905 |
| SolarCity | San Mateo, California | 2006 |
| Sonos | Santa Bárbara | 2002 |
| Sony Music | Nueva York | 1 de enero de 2009 |
| Southern Company | Atlanta | 1945 |
| Southern Pacific | San Francisco | 1865 |
| SpaceXAI | Área de la Bahía de San Francisco | 9 de marzo de 2023 |
| Spector | Saugerties | 1976 |
| Spectravideo | — | 1981 |
| Spectrum Brands | Middleton | 1906 |
| Springfield Armory | Geneseo | 1974 |
| Sprouts | Phoenix | julio 2002 |
| Stage 6 Films | Culver City | 2007 |