| Blackboard | Washington D. C. | 1997 |
| BlackRock | Nueva York | 1988 |
| Blackstone Group | Nueva York | 1985 |
| Blinding Edge Pictures | Berwyn | 1999 |
| Bluehost | Provo | 2022 |
| BlueStacks | Campbell | 2011 |
| Blur Studio | Venice | 1995 |
| BMC Software | Houston | 1980 |
| Borders | Ann Arbor | 1971 |
| BorgWarner | Auburn Hills | 1880 |
| Boston Scientific | Marlborough | 29 de junio de 1979 |
| Box | Redwood City | mayo 2009 |
| Box Office Mojo | — | 1999 |
| Broadcom | Palo Alto | 1961 |
| Broadwood | Nueva York, Londres | 1732 |
| Brocade Communications Systems | San José | 1995 |
| Brown-Forman | Louisville | 1870 |
| Browning Arms Company | Morgan | 1927 |
| Build-A-Bear Workshop | San Luis | 1997 |
| Bulova | Nueva York | 1875 |
| Bunge Limited | Hamilton, White Plains | 1818 |
| Burlington | Municipio de Florence | 1972 |
| Burroughs Corporation | Detroit, Misuri, San Luis | 1904 |
| BuzzFeed | Nueva York, Nueva York | 2006 |
| C. H. Robinson Worldwide | Eden Prairie | 1905 |
| Cadence Design Systems | San José | 1988 |
| Cambridge Analytica | Londres | 2014 |
| Cannondale Bicycle Corporation | Bethel | 1971 |
| Canoo | Torrance | 2017 |
| Cantor Fitzgerald | Nueva York | 1945 |
| Capital Group Companies | Los Ángeles | 1931 |
| Capital One | McLean | 1994 |
| Carfax | Centreville | 1984 |
| Cargill | Minnetonka | 1865 |
| CarMax | condado de Goochland | 1993 |
| Cartercar | Pontiac | 1905 |
| Case IH | Racine | 1984 |
| Cash App | — | 15 de octubre de 2013 |
| CBRE Group | Dallas, Los Ángeles | 1906 |
| CBS Corporation | CBS Building | 30 de noviembre de 1997 |
| Cedar Fair | Sandusky | 1983 |
| Celgene | Summit | 1986 |
| Cencora | Chesterbrook | 2001 |
| Cengage Learning | Stamford | 2000 |
| Century 21 Real Estate | Madison | 1971 |
| Cerebras | Sunnyvale, San Francisco | 2016 |
| CF Industries | Deerfield, Deerfield | 1946 |
| CH2M Hill | Meridian | 1946 |