| Cyan Worlds | Wilmington, Mead | 1987 |
| Dahon | Los Ángeles | 1982 |
| Dallas Semiconductor | Dallas | 1 de febrero de 1984 |
| Danelectro | Camarillo | 1947 |
| Darden Restaurants | Condado de Orange | 1968 |
| Datapoint | — | 1968 |
| DataStax | Santa Clara | abril 2010 |
| DDB Worldwide | Chicago, San Francisco, Londres | 1949 |
| Dean Foods | Dallas | 1925 |
| Dean Guitars | Tampa | 1976 |
| Deckers Outdoor Corporation | Goleta | 1973 |
| Deep Space Industries | Mountain View | 22 de enero de 2013 |
| Deere & Company | Moline | 1868 |
| Dell EMC | Hopkinton | agosto 1979 |
| Delta Air Lines | Atlanta | 17 de junio de 1929 |
| Depositphotos | Fort Lauderdale | 4 de noviembre de 2009 |
| Detroit Electric Car Company | Detroit | 1907 |
| Devon Energy | Oklahoma City | 1971 |
| Diamond-Star Motors | — | octubre 1985 |
| Dick's Sporting Goods | Coraopolis | 1948 |
| Digi-Key | Thief River Falls | 1972 |
| Digital Eclipse | California | 7 de agosto de 1992 |
| DigitalGlobe | Westminster | 1992 |
| DigitalOcean | Nueva York | agosto 2011 |
| Discovery, Inc. | Nueva York | 1982 |
| Dish | Meridian | 1996 |
| Disney Cruise Line | Celebration | 1995 |
| Disney Games Group | Glendale | 1994 |
| Disney Television Animation | Glendale | 5 de diciembre de 1984 |
| Disney-ABC Domestic Television | Burbank | 1983 |
| Doble | Detroit, Waltham | 1909 |
| Dodge | Dodge Building | 14 de diciembre de 1900 |
| Dollar General | Goodlettsville | 1939 |
| Dominion Energy | Richmond | 1983 |
| DoubleTree by Hilton | McLean | 1969 |
| Dover Corporation | Downers Grove | 1955 |
| Dow Chemical Company | Midland | 1897 |
| Dow Jones & Company | Nueva York | 1882 |
| Dr. Scholl's | Chicago, Londres | 1906 |
| Duke Energy | Charlotte | 1997 |
| Duracell | Chicago, Bethel | 1930 |
| DYMO Corporation | Berkeley | 1958 |
| E-Mu Systems | Scotts Valley | 1971 |
| E-ZPass | Wilmington | 1987 |
| EA Sports | Burnaby | 1991 |
| EarthLink | Atlanta, Pasadena, Atwater Village | 1994 |
| Eastman Chemical Company | Kingsport | 1920 |
| EBay | San José | 3 de septiembre de 1995 |